Ground truth labels challenge the validity of sepsis consensus definitions in critical illness.

ABSTRACT:

Background

Sepsis is the leading cause of death in the intensive care unit (ICU). Expediting its diagnosis, largely determined by clinical assessment, improves survival. Predictive and explanatory modelling of sepsis in the critically ill commonly bases both outcome definition and predictions on clinical criteria for consensus definitions of sepsis, leading to circularity. As a remedy, we collected ground truth labels for sepsis.

Methods

In the Ground Truth for Sepsis Questionnaire (GTSQ), senior attending physicians in the ICU documented daily their opinion on each patient's condition regarding sepsis as a five-category working diagnosis and nine related items. Working diagnosis groups were described and compared and their SOFA-scores analyzed with a generalized linear mixe

SUBMITTER: Lindner HA 

PROVIDER: S-EPMC8760797 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature