Co-evolutionary Signals Identify Burkholderia pseudomallei Survival Strategies in a Hostile Environment.

ABSTRACT: The soil bacterium Burkholderia pseudomallei is the causative agent of melioidosis and a significant cause of human morbidity and mortality in many tropical and subtropical countries. The species notoriously survives harsh environmental conditions but the genetic architecture for these adaptations remains unclear. Here we employed a powerful combination of genome-wide epistasis and co-selection studies (2,011 genomes), condition-wide transcriptome analyses (82 diverse conditions), and a gene knockout assay to uncover signals of "co-selection"-that is a combination of genetic markers that have been repeatedly selected together through B. pseudomallei evolution. These enabled us to identify 13,061 mutation pairs under co-selection in distinct genes and noncoding RNA. Genes under co-selection

SUBMITTER: Chewapreecha C 

PROVIDER: S-EPMC8760936 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature