New lessons on TDP-43 from old N. furzeri killifish.
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ABSTRACT:
SUBMITTER: Louka A
PROVIDER: S-EPMC8761016 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Publications
New lessons on TDP-43 from old N. furzeri killifish.
Louka Alexandra A Bagnoli Sara S Rupert Jakob J Esapa Benjamina B Tartaglia Gian Gaetano GG Cellerino Alessandro A Pastore Annalisa A Terzibasi Tozzini Eva E
Aging cell 20211223 1
Frontotemporal dementia and amyotrophic lateral sclerosis are fatal and incurable neurodegenerative diseases linked to the pathological aggregation of the TDP-43 protein. This is an essential DNA/RNA-binding protein involved in transcription regulation, pre-RNA processing, and RNA transport. Having suitable animal models to study the mechanisms of TDP-43 aggregation is crucial to develop treatments against disease. We have previously demonstrated that the killifish Nothobranchius furzeri offers ...[more]
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