Prospective real-time evaluation of the QTc interval variation after low-dose droperidol among emergency department patients.

ABSTRACT:

Objective

To assess the QTc interval variation after low-dose droperidol in a population of undifferentiated, stable, and non-agitated patients receiving droperidol in the emergency department.

Methods

Prospective cohort study of patients aged ≥12 years of age who received low-dose droperidol (≤ 2.5 mg) for indications other than acute behavioral disturbances. QTc intervals were monitored in real-time during pre-specified observation periods in the ED. Primary outcome was variation of QTc interval after droperidol administration, defined as the maximum delta (change) of QTc interval. Other outcomes included proportion of patients with a QTc ≥ 500 ms after droperidol, delta ≥ +60 ms, and incidence of clinical adverse events. Patients were monitored up to 30 min after IV bolus

SUBMITTER: Hernandez-Rodriguez L 

PROVIDER: S-EPMC8761164 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature