Excited-State Copper Catalysis for the Synthesis of Heterocycles.

ABSTRACT: Heterocycles are one of the largest groups of organic moieties with significant medicinal, chemical, and industrial applications. Herein, we report the discovery and development of visible-light-induced, synergistic excited-state copper catalysis using a combination of Cu(IPr)I as a catalyst and rac-BINAP as a ligand, which produces more than 10 distinct classes of heterocycles. The reaction tolerates a broad array of functional groups and complex molecular scaffolds, including derivatives of peptides, natural products, and marketed drugs. Preliminary mechanistic investigation suggests in situ generations of [Cu(BINAP)₂ ]⁺ and [Cu(IPr)₂ ]⁺ catalysts that work cooperatively under visible-light irradiation to facilitate catalytic carbo-aroylation o

SUBMITTER: Banerjee A 

PROVIDER: S-EPMC8761179 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature