Core promoter mutation contributes to abnormal gene expression in bladder cancer.

ABSTRACT:

Background

Bladder cancer is one of the most mortal cancers. Bladder cancer has distinct gene expression signature, highlighting altered gene expression plays important roles in bladder cancer etiology. However, the mechanism for how the regulatory disorder causes the altered expression in bladder cancer remains elusive. Core promoter controls transcriptional initiation. We hypothesized that mutation in core promoter abnormality could cause abnormal transcriptional initiation thereby the altered gene expression in bladder cancer.

Methods

In this study, we performed a genome-wide characterization of core promoter mutation in 77 Spanish bladder cancer cases.

Results

We identified 69 recurrent somatic mutations in 61 core promoters of 62 genes and 28 recurrent germline m

SUBMITTER: Huang T 

PROVIDER: S-EPMC8761283 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature