MiR-937-3p promotes metastasis and angiogenesis and is activated by MYC in lung adenocarcinoma.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is still one of the diseases with the highest mortality and morbidity, and lung adenocarcinoma (LUAD) accounts for more than half of all NSCLC cases in most countries. miRNA can be used as a potential biological marker and treatment for lung adenocarcinoma. However, the effect of miR-937-3p to the invasion and metastasis of LUAD cells is not clear.

Methods

miRNA microarray is used to analyze the expression of miRNA in lung adenocarcinoma tissue. Transwell migration, Wound-healing assay and Western blot analysis are used to analyze cell migration, invasion and epithelial-mesenchymal transition (EMT) capabilities. Tube formation is used to assess angiogenesis ability. In addition, dual luciferase reporter gene detection is used to

SUBMITTER: Ma Z 

PROVIDER: S-EPMC8761314 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature