Proteomics based markers of clinical pain severity in juvenile idiopathic arthritis.

ABSTRACT:

Introduction

Juvenile idiopathic arthritis (JIA) is a cluster of autoimmune rheumatic diseases occurring in children 16 years of age or less. While it is well-known that pain may be experienced during inflammatory and non-inflammatory states, much remains ambiguous regarding the molecular mechanisms that may drive JIA pain. Thus, in this pilot study, we explored the variability of the serum proteomes in relation to pain severity in a cohort of JIA patients.

Methods

Serum samples from 15 JIA patients (male and female, 12.7 ± 2.8 years of age) were assessed using liquid chromatography/mass spectrometry (LC/MS). Correlation analyses were performed to determine the relationships among protein levels and self-reported clinical pain severity. Additionally, how the expression of pa

SUBMITTER: Van Der Heijden H 

PROVIDER: S-EPMC8761318 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature