Left ventricular mass regression, all-cause and cardiovascular mortality in chronic kidney disease: a meta-analysis.

ABSTRACT:

Background

Cardiovascular disease is an important driver of the increased mortality associated with chronic kidney disease (CKD). Higher left ventricular mass (LVM) predicts increased risk of adverse cardiovascular outcomes and total mortality, but previous reviews have shown no clear association between intervention-induced LVM change and all-cause or cardiovascular mortality in CKD.

Methods

The primary objective of this meta-analysis was to investigate whether treatment-induced reductions in LVM over periods ≥12 months were associated with all-cause mortality in patients with CKD. Cardiovascular mortality was investigated as a secondary outcome. Measures of association in the form of relative risks (RRs) with associated variability and precision (95% confidence intervals [

SUBMITTER: Maki KC 

PROVIDER: S-EPMC8761349 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature