Core Hydrophobicity of Supramolecular Nanoparticles Induces NLRP3 Inflammasome Activation.

ABSTRACT: Designer nanomaterials capable of delivering immunomodulators to specific immune cells have been extensively studied. However, emerging evidence suggests that several of these nanomaterials can nonspecifically activate NLRP3 inflammasomes, an intracellular multiprotein complex controlling various immune cell functions, leading to undesirable effects. To understand what nanoparticle attributes activate inflammasomes, we designed a multiparametric polymer supramolecular nanoparticle system to modulate various surface and core nanoparticle-associated molecular patterns (NAMPs), one at a time. We also investigated several underlying signaling pathways, including lysosomal rupture-cathepsin B maturation and calcium flux-mitochondrial ROS production, to gain mechanistic insights into NAMPs-media

SUBMITTER: Nandi D 

PROVIDER: S-EPMC8761361 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature