Autophagy ATG16L1 rs2241880 impacts the colorectal cancer risk: A case-control study.

ABSTRACT:

Background

Despite many efforts to discover the important role of the autophagy process in the pathogenesis of colorectal cancer (CRC), the exact involved molecular mechanism still remains to be elucidated. Recently, a limited number of studies have been employed to discover the impact of autophagy genes' variants on the development and progression of CRC. Here, we evaluated the association between two single-nucleotide polymorphisms (SNPs) in the main components of the autophagy genes, ATG16L1 rs2241880, and ATG5 rs1475270, and the CRC risk in an Iranian population.

Methods

During this investigation, a total of 369 subjects, including 179 CRC patients and 190 non-cancer controls have been genotyped using Tetra-primer amplification refractory mutation system-polymerase chain

SUBMITTER: Jamali L 

PROVIDER: S-EPMC8761398 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature