Effects of IL-32 polymorphisms and IL-32 levels on the susceptibility and severity of coronary artery disease.

ABSTRACT:

Background

Interleukin-32 (IL-32) has long been proposed as a biomarker for coronary artery disease (CAD). We aimed to evaluate the association between IL-32 levels and coronary stenosis severity, IL-32 polymorphisms rs28372698 and rs4786370, and CAD susceptibility.

Methods

A total of 362 patients with definite or suspected CAD that underwent angiography were recruited (CAD group, n = 175; nonobstructive CAD group, n = 56; control group, n = 131). The severity of coronary stenosis was assessed using the Gensini score and the number of diseased vessels. IL-32 levels were determined using enzyme-linked immunosorbent assay. Gene polymorphisms were genotyped using PCR and sequencing techniques.

Results

IL-32 levels were significantly different at different levels of coron

SUBMITTER: Jin S 

PROVIDER: S-EPMC8761453 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature