Comparison of IL-6 measurement methods with a special emphasis on COVID-19 patients according to equipment and sample type.

ABSTRACT:

Background

Interleukin-6 (IL-6) is a multifunctional cytokine associated with various diseases, including coronavirus disease (COVID-19). Although IL-6 levels can be assessed using serum samples, use of the AFIAS (Boditech Med Inc.) automated immunoassay analyzer enables quick and simple measurement of IL-6 levels in both serum and whole blood specimens. This study aimed to assess the correlation between IL-6 measurements obtained from the AFIAS IL-6 assay and Elecsys IL-6 assay (Roche Diagnostics). Additionally, utilization of the AFIAS IL-6 assay was evaluated.

Methods

The IL-6 levels from 113 serum samples quantified using two assay systems were evaluated for their degree of correlation. Meanwhile, the linearity, analytical sensitivity, and precision/reproducibility of th

SUBMITTER: Choi YJ 

PROVIDER: S-EPMC8761465 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature