Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions.

ABSTRACT:

Background

Incidence and mortality of gastric cancer (GC) are high in Mongolia despite Helicobacter pylori in the Mongolian population being less virulent.

Aim

To evaluate gastric bacterial microbiota profiles in patients with GC and its precursor histological conditions.

Methods

We conducted a case-control study among 48 GC and 120 noncancer patients (20 normal gastric mucosa [control], 20 gastritis, 40 with atrophy and 40 intestinal metaplasia [IM]). We performed 16S rRNA gene amplicon sequencing and compared taxonomic and functional prediction profiles based on the diagnosis group and H pylori infection status.

Results

The highest overall bacterial alpha diversity metrics were observed in the control group, followed by the IM and cancer groups. The gastritis

SUBMITTER: Gantuya B 

PROVIDER: S-EPMC8761497 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature