Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes.

ABSTRACT: Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic cells induces dysregulation in innate immunity and enhances malaria pathogenesis. Treatment of cultured peripheral blood mononuclear cells (PBMCs) from healthy, malaria-naïve donors with physiological concentrations of PfHz can serve as an in vitro model to investigate cellular processes. Although disruptions in host ubiquitination processes are central to the pathogenesis of many diseases, this system remains unexplored in malaria. As such, we investigated the impact of PfHz on the temporal expression patterns of 84 genes involved i

SUBMITTER: Anyona SB 

PROVIDER: S-EPMC8761598 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature