High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions.

ABSTRACT: Background: Temporal interference (TI) stimulation is a new technique of non-invasive brain stimulation. Envelope-modulated waveforms with two high-frequency carriers can activate neurons in target brain regions without stimulating the overlying cortex, which has been validated in mouse brains. However, whether TI stimulation can work on the human brain has not been elucidated. Objective: To assess the effectiveness of the envelope-modulated waveform of TI stimulation on the human primary motor cortex (M1). Methods: Participants attended three sessions of 30-min TI stimulation during a random reaction time task (RRTT) or a serial reaction time task (SRTT). Motor cortex excitability was measured before and after TI stimulation. Results: In the RRTT experiment, on

SUBMITTER: Ma R 

PROVIDER: S-EPMC8761631 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature