Metformin Transport Rates Between Plasma and Red Blood Cells in Humans.

ABSTRACT:

Background

Metformin has been used for the treatment of type 2 diabetes for over 60 years; however, its mechanism of pharmacological action is not fully clear. Different hypotheses exist regarding metformin distribution and redistribution mechanisms between plasma and erythrocytes/red blood cells (RBCs).

Objective

We aimed to test the hypothesis that the metformin distribution between plasma and RBC occurs via concentration difference-driven passive transport and estimated transport rate coefficient values based on metformin concentration time series in plasma and RBCs from in vivo studies.

Methods

An ordinary differential equation (ODE) system with two compartments was used to describe diffusion-based passive transport between plasma and RBCs. Metformin concentration

SUBMITTER: Kurlovics J 

PROVIDER: S-EPMC8761711 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature