Age and sex effects on advanced white matter microstructure measures in 15,628 older adults: A UK biobank study.

ABSTRACT: A comprehensive characterization of the brain's white matter is critical for improving our understanding of healthy and diseased aging. Here we used diffusion-weighted magnetic resonance imaging (dMRI) to estimate age and sex effects on white matter microstructure in a cross-sectional sample of 15,628 adults aged 45-80 years old (47.6% male, 52.4% female). Microstructure was assessed using the following four models: a conventional single-shell model, diffusion tensor imaging (DTI); a more advanced single-shell model, the tensor distribution function (TDF); an advanced multi-shell model, neurite orientation dispersion and density imaging (NODDI); and another advanced multi-shell model, mean apparent propagator MRI (MAPMRI). Age was modeled using a data-driven statistical approach, and norma

SUBMITTER: Lawrence KE 

PROVIDER: S-EPMC8761720 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature