RapidET: a MEMS-based platform for label-free and rapid demarcation of tumors from normal breast biopsy tissues.

ABSTRACT: The rapid and label-free diagnosis of malignancies in ex vivo breast biopsy tissues has significant utility in pathology laboratories and operating rooms. We report a MEMS-based platform integrated with microchips that performs phenotyping of breast biopsy tissues using electrothermal sensing. The microchip, fabricated on a silicon substrate, incorporates a platinum microheater, interdigitated electrodes (IDEs), and resistance temperature detectors (RTDs) as on-chip sensing elements. The microchips are integrated onto the platform using a slide-fit contact enabling quick replacement for biological measurements. The bulk resistivity (ρ _B ), surface resistivity (ρ _S ), and thermal conductivity (k) of deparaffinized and formalin-fixed p

SUBMITTER: G K AV 

PROVIDER: S-EPMC8761751 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature