Longitudinal Prediction of Freezing of Gait in Parkinson's Disease: A Prospective Cohort Study.

ABSTRACT: Objective: Freezing of gait (FOG) is a disabling complication in Parkinson's disease (PD). Yet, studies on a validated model for the onset of FOG based on longitudinal observation are absent. This study aims to develop a risk prediction model to predict the probability of future onset of FOG from a multicenter cohort of Chinese patients with PD. Methods: A total of 350 patients with PD without FOG were prospectively monitored for ~2 years. Demographic and clinical data were investigated. The multivariable logistic regression analysis was conducted to develop a risk prediction model for FOG. Results: Overall, FOG was observed in 132 patients (37.70%) during the study period. At baseline, longer disease duration [odds ratio (OR) = 1.214, p = 0.008], higher total l

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8761770 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature