Associations between neurofilament light-chain protein, brain structure, and chronic kidney disease.

ABSTRACT:

Background

Neurofilament light-chain (NfL) protein is a blood-based marker of neuroaxonal injury. We sought to (1) compare plasma NfL levels in children with chronic kidney disease (CKD) and healthy peers, (2) characterize the relationship between NfL level and kidney function, and (3) evaluate NfL as a predictor of abnormal brain structure in CKD.

Methods

Sixteen children with CKD due to congenital kidney anomalies and 23 typically developing peers were included. Plasma NfL was quantified using single-molecule array immunoassay. Participants underwent structural magnetic resonance imaging. Multiple linear regression models were used to evaluate the association between plasma NfL levels, kidney function, and brain structure.

Results

An age × group interaction was iden

SUBMITTER: van der Plas E 

PROVIDER: S-EPMC8761779 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature