Radiomics Assessment of the Tumor Immune Microenvironment to Predict Outcomes in Breast Cancer.

ABSTRACT:

Background

The immune microenvironment of tumors provides information on prognosis and prediction. A prior validation of the immunoscore for breast cancer (IS_BC) was made on the basis of a systematic assessment of immune landscapes extrapolated from a large number of neoplastic transcripts. Our goal was to develop a non-invasive radiomics-based IS_BC predictive factor.

Methods

Immunocell fractions of 22 different categories were evaluated using CIBERSORT on the basis of a large, open breast cancer cohort derived from comprehensive information on gene expression. The IS_BC was constructed using the LASSO Cox regression model derived from the Immunocell type scores, with 479 quantified features in the intratumoral and peritumoral regions as obser

SUBMITTER: Han X 

PROVIDER: S-EPMC8761791 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature