Validation of digital microscopy: Review of validation methods and sources of bias.

ABSTRACT: Digital microscopy (DM) is increasingly replacing traditional light microscopy (LM) for performing routine diagnostic and research work in human and veterinary pathology. The DM workflow encompasses specimen preparation, whole-slide image acquisition, slide retrieval, and the workstation, each of which has the potential (depending on the technical parameters) to introduce limitations and artifacts into microscopic examination by pathologists. Performing validation studies according to guidelines established in human pathology ensures that the best-practice approaches for patient care are not deteriorated by implementing DM. Whereas current publications on validation studies suggest an overall high reliability of DM, each laboratory is encouraged to perform an individual validation study to

SUBMITTER: Bertram CA 

PROVIDER: S-EPMC8761960 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature