Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions.

ABSTRACT:

Objective

Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent cells are present in premalignant pancreatic intraepithelial neoplasia (PanIN) lesions, yet their effects on the disease are poorly characterised. It is currently unknown whether senolytic drugs, aimed at eliminating senescent cells from lesions, could be beneficial in blocking tumour development.

Design

To uncover the functions of senescent cells and their potential contribution to early pancreatic tumourigenesis, we isolated and characterised senescent cells from PanINs formed in a Kras-driven mouse model, and tested the consequences of their targeted elimination thro

SUBMITTER: Kolodkin-Gal D 

PROVIDER: S-EPMC8762039 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature