Ontology highlight
ABSTRACT:
SUBMITTER: Flores-Romero H
PROVIDER: S-EPMC8762556 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Flores-Romero Hector H Hohorst Lisa L John Malina M Albert Marie-Christine MC King Louise E LE Beckmann Laura L Szabo Tamas T Hertlein Vanessa V Luo Xu X Villunger Andreas A Frenzel Lukas P LP Kashkar Hamid H Garcia-Saez Ana J AJ
The EMBO journal 20211221 2
During apoptosis, the BCL-2-family protein tBID promotes mitochondrial permeabilization by activating BAX and BAK and by blocking anti-apoptotic BCL-2 members. Here, we report that tBID can also mediate mitochondrial permeabilization by itself, resulting in release of cytochrome c and mitochondrial DNA, caspase activation and apoptosis even in absence of BAX and BAK. This previously unrecognized activity of tBID depends on helix 6, homologous to the pore-forming regions of BAX and BAK, and can b ...[more]