Chikungunya Virus Vaccine Development: Through Computational Proteome Exploration for Finding of HLA and cTAP Binding Novel Epitopes as Vaccine Candidates.

ABSTRACT: Chikungunya virus is a major arbovirus of great public health concern in the whole world, but no vaccine is yet available, still advance therapeutic treatment and effective vaccines are in progress. The present multistep screening and structural binding analysis with CHIKV proteome exploration can be crucial in the development phase of CHIKV epitope based vaccine. The approach employed in two phases (i) Sequence based screening of peptides through propred and IEDB Server (ii) Structure based study through autodocking and NAMD VMD simulation analysis. Among all 29 extracted peptides, only two peptides ²LLANTTFPC¹⁰ of protein E3 and ⁹⁸VNSVAIPLL¹⁰⁶ of protein nsP3 were observed most prominent over all consider parameters such as peptide conserve nat

SUBMITTER: Sharma P 

PROVIDER: S-EPMC8762984 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature