Late toxicity and outcomes following radiation therapy for chest wall sarcomas in pediatric patients.

ABSTRACT:

Purpose

To investigate the contribution of radiation therapy to acute and late toxicity in pediatric chest wall sarcoma patients and evaluate dosimetric correlates of higher incidence toxicities such as scoliosis and pneumonitis.

Methods and materials

The data from 23 consecutively treated pediatric patients with chest wall sarcomas of various histologies (desmoid, Ewing, rhabdomyosarcoma, nonrhabdomyosarcoma-soft tissue sarcomas) were reviewed to evaluate the relationship between end-organ radiation dose, clinical factors, and the risk of subsequent late effects (scoliosis, pneumonitis). Cobb angles were used to quantify the extent of scoliosis. Doses to the spine and lung were calculated from the radiation treatment plan.

Results

The range of scoliosis identified on

SUBMITTER: Lucas JT 

PROVIDER: S-EPMC8763014 | biostudies-literature | 2017 Nov - Dec

REPOSITORIES: biostudies-literature