MRI-Based Radiomic Signature Identifying Secondary Loss of Response to Infliximab in Crohn's Disease.

ABSTRACT: Up to 50% of patients with Crohn's disease (CD) experience secondary loss of response (SLR) to infliximab. Patients with SLR may show clinical signs of iron deficiency as a result of inflammation despite being iron-replete. The magnetic resonance imaging (MRI)-based radiomic index, R2^*, can detect changes in iron metabolism. Therefore, the R2^* parameter has considerable potential for detection of SLR to infliximab. The aims of this study were to explore the correlation between R2^* and inflammation and to develop a non-invasive nomogram based on R2^* to identify SLR to infliximab in patients with CD. Three hundred and twenty-two infliximab-treated patients with CD who underwent magnetic resonance enterography within 2 weeks before or after 54 weeks

SUBMITTER: Feng J 

PROVIDER: S-EPMC8763017 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature