Protracted yet Coordinated Differentiation of Long-Lived SARS-CoV-2-Specific CD8⁺ T Cells during Convalescence.

ABSTRACT: CD8⁺ T cells can potentiate long-lived immunity against COVID-19. We screened longitudinally-sampled convalescent human donors against SARS-CoV-2 tetramers and identified a participant with an immunodominant response against residues 322 to 311 of nucleocapsid (Nuc_322-331), a peptide conserved in all variants of concern reported to date. We conducted 38-parameter cytometry by time of flight on tetramer-identified Nuc_322-331-specific CD8⁺ T cells and on CD4⁺ and CD8⁺ T cells recognizing the entire nucleocapsid and spike proteins, and took 32 serological measurements. We discovered a coordination of the Nuc_322-331-specific CD8⁺ T response with both the CD4⁺ T cell and Ab pillars of adaptive imm

SUBMITTER: Ma T 

PROVIDER: S-EPMC8763019 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature