Functional rejuvenation of aged neural stem cells by Plagl2 and anti-Dyrk1a activity.

ABSTRACT: The regenerative potential of neural stem cells (NSCs) declines during aging, leading to cognitive dysfunctions. This decline involves up-regulation of senescence-associated genes, but inactivation of such genes failed to reverse aging of hippocampal NSCs. Because many genes are up-regulated or down-regulated during aging, manipulation of single genes would be insufficient to reverse aging. Here we searched for a gene combination that can rejuvenate NSCs in the aged mouse brain from nuclear factors differentially expressed between embryonic and adult NSCs and their modulators. We found that a combination of inducing the zinc finger transcription factor gene Plagl2 and inhibiting Dyrk1a, a gene associated with Down syndrome (a genetic disorder known to accelerate aging), rejuv

SUBMITTER: Kaise T 

PROVIDER: S-EPMC8763050 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature