Evolutionary Implications of the RNA N6-Methyladenosine Methylome in Plants.

ABSTRACT: Epigenetic modifications play important roles in genome evolution and innovation. However, most analyses have focused on the evolutionary role of DNA modifications, and little is understood about the influence of posttranscriptional RNA modifications on genome evolution. To explore the evolutionary significance of RNA modifications, we generated transcriptome-wide profiles of N6-methyladenosine (m6A), the most prevalent internal modification of mRNA, for 13 representative plant species spanning over half a billion years of evolution. These data reveal the evolutionary conservation and divergence of m6A methylomes in plants, uncover the preference of m6A modifications on ancient orthologous genes, and demonstrate less m6A divergence between orthologous gene pairs with earlier evolutionary o

SUBMITTER: Miao Z 

PROVIDER: S-EPMC8763109 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature