Circulating Plasma Biomarkers in Biopsy-Confirmed Kidney Disease.

ABSTRACT:

Background and objectives

Biomarkers for noninvasive assessment of histopathology and prognosis are needed in patients with kidney disease.

Design, setting, participants, & measurements

Using a proteomics assay, we measured a multimarker panel of 225 circulating plasma proteins in a prospective cohort study of 549 individuals with biopsy-confirmed kidney diseases and semiquantitative assessment of histopathology. We tested the associations of each biomarker with histopathologic lesions and the risks of kidney disease progression (defined as ≥40% decline in eGFR or initiation of KRT) and death.

Results

After multivariable adjustment and correction for multiple testing, 46 different proteins were associated with histopathologic lesions. The top-performing markers positi

SUBMITTER: Schmidt IM 

PROVIDER: S-EPMC8763150 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature