Platelet Abnormalities in CKD and Their Implications for Antiplatelet Therapy.

ABSTRACT: Patients with CKD display a significantly higher risk of cardiovascular and thromboembolic complications, with around half of patients with advanced CKD ultimately dying of cardiovascular disease. Paradoxically, these patients also have a higher risk of hemorrhages, greatly complicating patient therapy. Platelets are central to hemostasis, and altered platelet function resulting in either platelet hyper- or hyporeactivity may contribute to thrombotic or hemorrhagic complications. Different molecular changes have been identified that may underlie altered platelet activity and hemostasis in CKD. In this study, we summarize the knowledge on CKD-induced aberrations in hemostasis, with a special focus on platelet abnormalities. We also discuss how prominent alterations in vascular integrity, co

SUBMITTER: Baaten CCFMJ 

PROVIDER: S-EPMC8763166 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature