Rel/NF-κB Transcription Factors Emerged at the Onset of Opisthokonts.

ABSTRACT: The Rel/NF-κB transcription factor family has myriad roles in immunity, development, and differentiation in animals, and was considered a key innovation for animal multicellularity. Rel homology domain-containing proteins were previously hypothesized to have originated in a last common ancestor of animals and some of their closest unicellular relatives. However, key taxa were missing from previous analyses, necessitating a systematic investigation into the distribution and evolution of these proteins. Here, we address this knowledge gap by surveying taxonomically broad data from eukaryotes, with a special emphasis on lineages closely related to animals. We report an earlier origin for Rel/NF-κB proteins than previously described, in the last common ancestor of animals and fungi, and show t

SUBMITTER: Leger MM 

PROVIDER: S-EPMC8763368 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature