Cytokine Release Syndrome and Immune-Related Pneumonitis Associated With Tumor Progression in a Pulmonary Pleomorphic Carcinoma Treated With Nivolumab Plus Ipilimumab Treatment: A Case Report.
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ABSTRACT:
SUBMITTER: Kunimasa K
PROVIDER: S-EPMC8763637 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
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Cytokine Release Syndrome and Immune-Related Pneumonitis Associated With Tumor Progression in a Pulmonary Pleomorphic Carcinoma Treated With Nivolumab Plus Ipilimumab Treatment: A Case Report.
Kunimasa Kei K Inoue Takako T Matsueda Katsunori K Kawamura Takahisa T Tamiya Motohiro M Nishino Kazumi K Kumagai Toru T
JTO clinical and research reports 20211231 2
Effective control of severe immune-related adverse events, including cytokine release syndrome (CRS), is essential for the success of immunotherapy. We present a case of a granulocyte colony-stimulating factor-producing pleomorphic lung carcinoma treated with nivolumab plus ipilimumab which developed CRS and severe immune-related pneumonitis. The effect of immunotherapy was heterogeneous; gastric metastasis was eliminated, but the pulmonary lesion had primary resistance. Steroid and tocilizumab ...[more]
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