Metastatic colorectal cancer and type 2 diabetes: prognostic and genetic interactions.

ABSTRACT: The present study was undertaken to analyze prognostic and genetic interactions between type 2 diabetes and metastatic colorectal cancer. Patients' survival was depicted through the Kaplan-Meier product limit method. Prognostic factors were examined through the Cox proportional-hazards regression model, and associations between diabetes and clinical-pathologic variables were evaluated by the χ² test. In total, 203 metastatic colorectal cancer patients were enrolled. Lymph nodes (P = 0.0004) and distant organs (> 2 distant sites, P = 0.0451) were more frequently involved in diabetic patients compared with those without diabetes. Diabetes had an independent statistically significant negative prognostic value for survival. Highly selected patients with cancer and/or diabetes as the

SUBMITTER: Ottaiano A 

PROVIDER: S-EPMC8763648 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature