Upregulated functional gene expression programmes in tumour pericytes mark progression in patients with low-grade glioma.

ABSTRACT: Pericytes conceivably play important roles in the tumour microenvironment of glioblastoma multiforme (GBM) by allowing for an aberrant vasculature and acting as a component in the perivascular niche that supports glioma stem-like cells. However, a lack of specific markers has hampered in-depth elucidation of the functional contribution of pericytes to GBM. This study provides a comprehensive computational biology approach to annotate pericyte marker genes in the GBM vasculature through integration of data from single-cell RNA-sequencing studies of both mouse and human tissue, as well as bulk tumour and healthy tissue gene expression data from patients with GBM. We identified distinct vascular- and immune-related gene expression programmes in tumour pericytes that we assessed for associatio

SUBMITTER: Oudenaarden C 

PROVIDER: S-EPMC8763650 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature