Genetic and environmental risk factors for reticular pseudodrusen in the EUGENDA study.

ABSTRACT:

Purpose

The purpose of this study was to analyze genetic and nongenetic associations with reticular pseudodrusen (RPD) in patients with and without age-related macular degeneration (AMD).

Methods

This case-control study included 2,719 consecutive subjects from the prospective multicenter European Genetic Database (EUGENDA). Color fundus photographs and optical coherence tomography (OCT) scans were evaluated for the presence of AMD and RPD. Association of RPD with 39 known AMD polymorphisms and various nongenetic risk factors was evaluated. Stepwise backward variable selection via generalized linear models (GLMs) was performed based on models including the following: a) age, sex, and genetic factors and b) all predictors. Receiver operating characteristic (ROC) curves and the

SUBMITTER: Altay L 

PROVIDER: S-EPMC8763662 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature