Roles of Epithelial and Mesenchymal TRP Channels in Mediating Inflammatory Fibrosis.

ABSTRACT: The maintenance of normal vision is dependent on preserving corneal transparency. For this to occur, this tissue must remain avascular and its stromal architecture needs to be retained. Epithelial transparency is maintained provided the uppermost stratified layers of this tissue are composed of terminally differentiated non-keratinizing cells. In addition, it is essential that the underlying stromal connective tissue remains avascular and scar-free. Keratocytes are the source of fibroblasts that are interspersed within the collagenous framework and the extracellular matrix. In addition, there are sensory nerve fibers whose lineage is possibly either neural crest or mesenchymal. Corneal wound healing studies have been undertaken to delineate the underlying pathogenic responses that result i

SUBMITTER: Okada Y 

PROVIDER: S-EPMC8763672 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature