Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters.

ABSTRACT: Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After its release from presynaptic nerve terminals, glutamate is quickly removed from the synaptic cleft by excitatory amino acid transporters (EAATs) 1-5, a subfamily of glutamate transporters. The five proteins utilize a complex transport stoichiometry that couples glutamate transport to the symport of three Na⁺ ions and one H⁺ in exchange with one K⁺ to accumulate glutamate against up to 10⁶-fold concentration gradients. They are also anion-selective channels that open and close during transitions along the glutamate transport cycle. EAATs belong to a larger family of secondary-active transporters, the SLC1 family, which also includes purely Na⁺

SUBMITTER: Alleva C 

PROVIDER: S-EPMC8763778 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature