A catalog of curated breast cancer genes.

ABSTRACT:

Purpose

Decades of research have identified multiple genetic variants associated with breast cancer etiology. However, there is no database that archives breast cancer genes and variants responsible for predisposition. We set out to build a dynamic repository of curated breast cancer genes.

Methods

A comprehensive literature search was performed in PubMed and Google Scholar, followed by data extraction and harmonization for downstream analysis.

Results

Using a subset of 345 studies, we cataloged 652 breast cancer-associated loci across the genome. A majority of these were present in the non-coding region (i.e., intergenic (101) and intronic (345)), whereas only 158 were located within an exon. Using the odds ratio, we identified 429 loci to increase the disease risk a

SUBMITTER: Bose M 

PROVIDER: S-EPMC8763822 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature