Ontology highlight
ABSTRACT:
SUBMITTER: Lai X
PROVIDER: S-EPMC8763928 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Lai Xiangfeng X Han Mei-Ling ML Ding Yue Y Chow Seong Hoong SH Le Brun Anton P AP Wu Chun-Ming CM Bergen Phillip J PJ Jiang Jhih-Hang JH Hsu Hsien-Yi HY Muir Benjamin W BW White Jacinta J Song Jiangning J Li Jian J Shen Hsin-Hui HH
Nature communications 20220117 1
A depleted antimicrobial drug pipeline combined with an increasing prevalence of Gram-negative 'superbugs' has increased interest in nano therapies to treat antibiotic resistance. As cubosomes and polymyxins disrupt the outer membrane of Gram-negative bacteria via different mechanisms, we herein examine the antimicrobial activity of polymyxin-loaded cubosomes and explore an alternative strategy via the polytherapy treatment of pathogens with cubosomes in combination with polymyxin. The polythera ...[more]