Radiomics analysis improves ¹⁸FDG PET/CT-based risk stratification of cytologically indeterminate thyroid nodules.

ABSTRACT:

Purpose

As ~25% of cytologically indeterminate thyroid nodules harbour malignancy, diagnostic lobectomy is still performed in many cases. ¹⁸FDG PET/CT rules out malignancy in visually negative nodules; however, none of the currently available interpretation criteria differentiates malignant from benign ¹⁸FDG-avid nodules. We evaluated the ability of PET metrics and radiomics features (RFs) to predict final diagnosis of ¹⁸FDG-avid cytologically indeterminate thyroid nodules.

Methods

Seventy-eight patients were retrospectively included. After volumetric segmentation of each thyroid lesion, 4 PET metrics and 107 RFs were extracted. A logistic regression was performed including thyroid stimulating hormone, PET metrics, and RFs to assess their pre

SUBMITTER: Giovanella L 

PROVIDER: S-EPMC8763930 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature