Regional uptakes from early-frame amyloid PET and ¹⁸F-FDG PET scans are comparable independent of disease state.

ABSTRACT:

Purpose

Positron emission tomography (PET) imaging with amyloid-beta (Aβ) tracers and 2-[18F] fluoro-2-Deoxy-D-glucose (¹⁸F-FDG) is extensively employed in Alzheimer's disease (AD) studies as biomarkers of AD pathology and neurodegeneration. To reduce cost and additional burdens to the patient, early-frame uptake during Aβ PET scanning has been proposed as a surrogate measure of regional glucose metabolism. Considering the disease state specific impact of AD on neurovascular coupling, we investigated to what extent the information captured in the early frames of an Aβ-PET (¹⁸F-florbetapir or ¹⁸F-florbetaben) scan is comparable to that of a ¹⁸F-FDG PET scan, independent of disease state.

Method

A partial correlation was performed on

SUBMITTER: Myoraku A 

PROVIDER: S-EPMC8763988 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature