Extracting phylogenetic dimensions of coevolution reveals hidden functional signals.

ABSTRACT: Despite the structural and functional information contained in the statistical coupling between pairs of residues in a protein, coevolution associated with function is often obscured by artifactual signals such as genetic drift, which shapes a protein's phylogenetic history and gives rise to concurrent variation between protein sequences that is not driven by selection for function. Here, we introduce a background model for phylogenetic contributions of statistical coupling that separates the coevolution signal due to inter-clade and intra-clade sequence comparisons and demonstrate that coevolution can be measured on multiple phylogenetic timescales within a single protein. Our method, nested coevolution (NC), can be applied as an extension to any coevolution metric. We use NC to demonstra

SUBMITTER: Colavin A 

PROVIDER: S-EPMC8764114 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature