Skin Autofluorescence, a Noninvasive Biomarker for Advanced Glycation End-products, Is Associated With Sarcopenia.

ABSTRACT:

Background

Accumulation of advanced glycation end-products (AGEs) in skeletal muscle has been implicated in development of sarcopenia.

Aim

To obtain further insight in the pathophysiology of sarcopenia, we studied its relationship with skin AGEs in the general population.

Methods

In a cross-sectional analysis, 2744 participants of northern European background, mean age 74.1 years, were included from the Rotterdam Study. Skin AGEs were measured as skin autofluorescence (SAF) using AGE ReaderTM, appendicular skeletal mass index (ASMI) using insight dual-energy X-ray absorptiometry, hand grip strength (HGS) using a hydraulic hand dynamometer, and, in a subgroup, gait speed (GS) measured on an electronic walkway (n = 2080). We defined probable sarcopenia (low HGS) and con

SUBMITTER: Waqas K 

PROVIDER: S-EPMC8764216 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature