Ontology highlight
ABSTRACT:
SUBMITTER: Xia D
PROVIDER: S-EPMC8764260 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Xia Dan D Zhang Xinyang X Deng Di D Ma Xiaoyan X Masri Samer S Wang Jianzheng J Bao Shaowen S Hu Songnian S Zhou Qiang Q
Frontiers in pharmacology 20220104
Effectively enhancing the activity of inhibitory neurons has great therapeutic potentials since their reduced function/activity has significant contributions to pathology in various brain diseases. We showed previously that NMDAR positive allosteric modulator GNE-8324 and M-8324 selectively increase NMDAR activity on the inhibitory neurons and elevates their activity <i>in vitro</i> and <i>in vivo.</i> Here we examined the impact of long-term administering M-8324 on the functions and transcripti ...[more]