Serum Vitamin D: Correlates of Baseline Concentration and Response to Supplementation in VITAL-DKD.

ABSTRACT:

Context

The effect of daily vitamin D supplementation on the serum concentration of vitamin D (the parent compound) may offer insight into vitamin D disposition.

Objective

To assess the total serum vitamin D response to vitamin D3 supplementation and whether it varies according to participant characteristics. To compare results with corresponding results for total serum 25-hydroxyvitamin D [25(OH)D], which is used clinically and measured in supplementation trials.

Design

Exploratory study within a randomized trial.

Intervention

2000 International Units of vitamin D3 per day (or matching placebo).

Setting

Community-based.

Participants

161 adults (mean ± SD age 70 ± 6 years; 66% males) with type 2 diabetes.

Main outcome measures

Changes in to

SUBMITTER: Best CM 

PROVIDER: S-EPMC8764322 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature