Serum Estradiol and 20 Site-Specific Cancers in Women: Mendelian Randomization Study.

ABSTRACT:

Context

The causal role of endogenous estradiol in cancers other than breast and endometrial cancer remains unclear.

Objective

This Mendelian randomization study assessed the causal associations of endogenous 17β-estradiol (E2), the most potent estrogen, with cancer risk in women.

Methods

As primary genetic instrument, we used a genetic variant in the CYP19A1 gene that is strongly associated with serum E2 levels. Summary statistics genetic data for the association of the E2 variant with breast, endometrial, and ovarian cancer were obtained from large-scale consortia. We additionally estimated the associations of the E2 variant with any and 20 site-specific cancers in 198 825 women of European descent in UK Biobank. Odds ratios (OR) of cancer per 0.01 unit increase in

SUBMITTER: Larsson SC 

PROVIDER: S-EPMC8764348 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature