In silico analyses of neuropeptide-like protein (NLP) profiles in parasitic nematodes.

ABSTRACT: Nematode parasite infections cause disease in humans and animals and threaten global food security by reducing productivity in livestock and crop farming. The escalation of anthelmintic resistance in economically important nematode parasites underscores the need for the identification of novel drug targets in these worms. Nematode neuropeptide signalling is an attractive system for chemotherapeutic exploitation, with neuropeptide G-protein coupled receptors (NP-GPCRs) representing the lead targets. In order to successfully validate NP-GPCRs for parasite control it is necessary to characterise their function and importance to nematode biology. This can be aided through identification of receptor activating ligand(s) via deorphanisation. Such efforts require the identification of all neurope

SUBMITTER: McKay FM 

PROVIDER: S-EPMC8764417 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature